A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Fluorine Atoms on C6H5-Corrole Affect the Interaction with Mpro and PLpro Proteases of SARS-CoV-2: Molecular Docking and 2D-QSAR ApproachesArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] 2D-QSAR 3CL pro acute respiratory syndrome binding binding affinity Compound compounds coronavirus correlation corroles cysteine protease decrease derivative docking score evaluated fluorine in silico in vitro In vitro assay increase in indicated inhibitor insertions Interaction M pro molecular docking molecular docking. MPro NMR nuclear Papain-like protease parameter physical-chemical PLPro protease Quantitative Region SARS-CoV-2 SARS-CoV-2 replication separated target the binding affinity two-dimensional was obtained [DOI] 10.3390/ijms231810936 PMC 바로가기
Two-stage hybrid network for segmentation of COVID-19 pneumonia lesions in CT images: a multicenter studyCT 이미지에서 COVID-19 폐렴 병변 분할을 위한 2단계 하이브리드 네트워크: 다기관 연구Multicenter Study Published on 2022-09-012022-09-11 Journal: Medical & biological engineering & computing [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy approach Automatic automatically characteristic Chest computed tomography Computed tomography COVID-19 COVID-19 diagnosis COVID-19 pneumonia Diagnosis Dice evaluated GPU hospitals identify Infected lesion segmentation lesion limitations lung manifestation memory multicenter outbreak Pneumonia pneumonia lesion Prognosis radiologist Radiologists regions required Screening Screening. sensitivity Seven specificity two-dimensional [DOI] 10.1007/s11517-022-02619-8 PMC 바로가기 [Article Type] Multicenter Study
Directional mutation and crossover boosted ant colony optimization with application to COVID-19 X-ray image segmentationResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, 치료기술, [키워드] Accuracy ACO Algorithm Ant colony optimization competing COVID-19 COVID-19 X-ray directional ENhance experiment experiments faster Image segmentation IMPROVE increase Local Mutation optimization Other Swarm intelligence threshold two-dimensional Validity were used X-ray [DOI] 10.1016/j.compbiomed.2022.105810 [Article Type] Research article
Automated screening of COVID-19 using two-dimensional variational mode decomposition and locally linear embeddingResearch article Published on 2022-09-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 진단, 치료기술, [키워드] Accuracy Algorithm assist auxiliary can be used Chest radiography COVID-19 COVID-19 diagnosis Diagnosis function Gabor filter intrinsic linear Locally linear embedding offer parameter Particle swarm optimization PCA physician Physicians Precision principal component analysis recall reduction shown support vector machine two-dimensional Two-dimensional variational mode decomposition [DOI] 10.1016/j.bspc.2022.103889 [Article Type] Research article
Two-dimensional reciprocal cross entropy multi-threshold combined with improved firefly algorithm for lung parenchyma segmentation of COVID-19 CT imageResearch article Published on 2022-09-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 치료기술, [키워드] Accuracy Algorithm arteries average consolidation COVID-19 cross Diagnosis Features Freeman chain code ground-glass opacity Improved firefly algorithm information initial lesion lung Lung CT lung lobe lung lobes lung parenchyma Lungs Multi-threshold segmentation processed Spatial neighborhood information threshold two-dimensional [DOI] 10.1016/j.bspc.2022.103933 [Article Type] Research article
A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination Research Published on 2022-08-222022-10-05 Journal: Nature nanotechnology [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome anti-SARS-CoV-2 association binding caused cells coronavirus Delta effective eliminated enzyme exhibit facilitate Host human airway epithelial Infection inhibiting macrophages mice omicron Organoid pandemic phagocytosed promote Receptor binding domain reduce Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selective the spike protein Therapeutic strategies therapy two-dimensional variants of concern virus virus elimination virus entry widespread wild-type SARS-CoV-2 [DOI] 10.1038/s41565-022-01177-2 [Article Type] Research
Artificial intelligence model on chest imaging to diagnose COVID-19 and other pneumonias: A systematic review and meta-analysisReview article Published on 2022-08-182022-10-05 Journal: European Journal of Radiology Open [Category] 진단, [키워드] 2Dtwo-dimensional 3Dthree-dimensional 95 % CI Accuracy AIartificial intelligence area under the curve article artificial intelligence AUC AUCarea under the curve average C-reactive protein calculate Characteristics chest imaging chest X-ray CNNConvolutional neural network Cochrane Library Computed tomography Convolutional neural network Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 COVID‐19 CRPC-reactive protein CTComputed Tomography CXRChest X-Ray Deep Learning Method diagnose diagnosing diagnostic disease for inclusion Future Generalizability GGOground-glass opacities Ground-glass opacities heterogeneity IMPROVE K-nearest neighbor KNNK-nearest neighbor LASSOleast absolute shrinkage and selection operator least absolute shrinkage and selection operator less machine learning MEERS-COVMiddle East respiratory syndrome coronavirus Meta-analysis Methodological quality methodology Middle East respiratory syndrome Coronavirus MLmachine learning negative likelihood ratio objective participant performed PLRnegative likelihood ratio PLRpositive likelihood ratio Pneumonia positive likelihood ratio predictive models QUADAS-2 Quality radiologist random-effects model regions of interest Research researcher Result retrieved Reverse transcriptase polymerase chain reaction ROIregions of interest RT-PCRReverse transcriptase polymerase chain reaction SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome score screened searched sensitivity Sensitivity and specificity Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 specificity SROCsummary receiver operating characteristic summary receiver operating characteristic support vector machine SVMSupport vector machine systematic review three-dimensional total score two-dimensional Web of Science were used [DOI] 10.1016/j.ejro.2022.100438 [Article Type] Review article
Predictive value of neutrophil-to-lymphocyte ratio for the fatality of COVID-19 patients complicated with cardiovascular diseases and/or risk factors Research Published on 2022-08-102022-10-05 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료법, 치료제, [키워드] Analysis baseline cardiovascular disease characteristic Characteristics characterized clinical implication clinical parameter Cluster conducted COVID-19 patient COVID-19 patients Cox proportional hazard cumulative mortality diagnostic disease severity fatality Follow-up groups high mortality hospitalized COVID-19 patient implication In-hospital death increase in independent Kaplan–Meier method log-rank test Mortality Neutrophil-to-lymphocyte ratio NLR overlap Patient patients with COVID-19 poor prognosis Predictive value previous study prognostic Prognostic factor quartile Regression model reported risk factor ROC selected significant difference significantly increased survival survival analysis the timing two-dimensional was tested [DOI] 10.1038/s41598-022-17567-4 [Article Type] Research
Automated diagnosis of COVID stages from lung CT images using statistical features in 2-dimensional flexible analytic wavelet transformResearch article Published on 2022-07-012022-10-05 Journal: Biocybernetics and Biomedical Engineering [Category] 치료기술, [키워드] Accuracy Algorithm applied approach assist chest imaging chest X-ray Computed tomography contagious COVID COVID-19 COVID-19 epidemic CT scan demonstrated detect diagnosed Diagnosis early stage FAWT based image decomposition feature Feature extraction Features flexible help identify illnesses image classification lung Lung CT machine learning Medical imaging outcomes PCA physical principal component analysis problems progression Respiratory system robust sensitivity specificity Spread Stage statistical student two-dimensional venous virus X-ray [DOI] 10.1016/j.bbe.2022.06.005 [Article Type] Research article